TY - JOUR
T1 - Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density
AU - Kosturakis, Alyssa K.
AU - He, Zijing
AU - Li, Yan
AU - Boyette-Davis, Jessica A.
AU - Shah, Nina
AU - Thomas, Sheeba K.
AU - Zhang, Haijun
AU - Vichaya, Elisabeth G.
AU - Wang, Xin Shelley
AU - Wendelschafer-Crabb, Gwen
AU - Kennedy, William R.
AU - Simone, Donald A.
AU - Cleeland, Charles S.
AU - Dougherty, Patrick M.
N1 - Publisher Copyright:
© 2014 by American Society of Clinical Oncology.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Purpose: The goal in this study was to determine the incidence of subclinical neuropathy in treatment-naive patients with multiple myeloma (MM) with no history of peripheral neuropathy using quantitative sensory tests (QSTs) and its correlation with innervation density of the extremities using noninvasive laser reflectance confocal microscopy.Conclusion: Patients with MM commonly present with sensory and sensorimotor deficits before undergoing treatment, and these deficits seem to result from disease-related decreases in peripheral innervation density.Patients and Methods: QST results were collected for 27 patients with a diagnosis of MM and compared with data collected from 30 age-and sex-matched healthy volunteers. Skin temperature, sensorimotor function (grooved pegboard test), and detection thresholds for temperature, sharpness, and low-threshold mechanical stimuli (von Frey monofilaments and bumps detection test) were measured. Meissner's corpuscle (MC) density in the fingertips was assessed using in vivo laser reflectance confocal microscopy.Results: Patients showed a high incidence (> 80%) of ≥ one subclinical QST deficit. These included increased von Frey, bumps, and warmth detection thresholds as compared with healthy volunteers. Patients also showed increases in cold pain, sensorimotor deficits (grooved pegboard test), and higher overall neuropathy scores. MC density was significantly lower in patients than controls and showed significant inverse correlation with bumps detection threshold.
AB - Purpose: The goal in this study was to determine the incidence of subclinical neuropathy in treatment-naive patients with multiple myeloma (MM) with no history of peripheral neuropathy using quantitative sensory tests (QSTs) and its correlation with innervation density of the extremities using noninvasive laser reflectance confocal microscopy.Conclusion: Patients with MM commonly present with sensory and sensorimotor deficits before undergoing treatment, and these deficits seem to result from disease-related decreases in peripheral innervation density.Patients and Methods: QST results were collected for 27 patients with a diagnosis of MM and compared with data collected from 30 age-and sex-matched healthy volunteers. Skin temperature, sensorimotor function (grooved pegboard test), and detection thresholds for temperature, sharpness, and low-threshold mechanical stimuli (von Frey monofilaments and bumps detection test) were measured. Meissner's corpuscle (MC) density in the fingertips was assessed using in vivo laser reflectance confocal microscopy.Results: Patients showed a high incidence (> 80%) of ≥ one subclinical QST deficit. These included increased von Frey, bumps, and warmth detection thresholds as compared with healthy volunteers. Patients also showed increases in cold pain, sensorimotor deficits (grooved pegboard test), and higher overall neuropathy scores. MC density was significantly lower in patients than controls and showed significant inverse correlation with bumps detection threshold.
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U2 - 10.1200/JCO.2013.54.5418
DO - 10.1200/JCO.2013.54.5418
M3 - Article
C2 - 25154818
AN - SCOPUS:84907588729
SN - 0732-183X
VL - 32
SP - 3156
EP - 3162
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 28
ER -