Successful management of hydroxyurea-induced leg ulcers in essential thrombocythemia: Report of 3 cases

Jihane Abou Rahal; Rim S. Ishak; Zaher K. Otrock; Joseph E. Maakaron; Samer Ghosn; Ali T. Taher

doi:10.4274/Tjh.2012.0134

Successful management of hydroxyurea-induced leg ulcers in essential thrombocythemia: Report of 3 cases

Jihane Abou Rahal, Rim S. Ishak, Zaher K. Otrock, Joseph E. Maakaron, Samer Ghosn, Ali T. Taher

Research output: Contribution to journal › Review article › peer-review

Abstract

Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.

Original language	English (US)
Pages (from-to)	184-187
Number of pages	4
Journal	Turkish Journal of Hematology
Volume	30
Issue number	2
DOIs	https://doi.org/10.4274/Tjh.2012.0134
State	Published - 2013
Externally published	Yes

Keywords

Essential thrombocythemia
Hydroxyurea
Interferon
Leg ulcers

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title = "Successful management of hydroxyurea-induced leg ulcers in essential thrombocythemia: Report of 3 cases",

abstract = "Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.",

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AU - Maakaron, Joseph E.

AU - Ghosn, Samer

AU - Taher, Ali T.

PY - 2013

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N2 - Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.

AB - Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.

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KW - Hydroxyurea

KW - Interferon

KW - Leg ulcers

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Successful management of hydroxyurea-induced leg ulcers in essential thrombocythemia: Report of 3 cases

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