Abstract
We report a case of natural killer cell large granular lymphocytic (NK-LGL) leukaemia successfully treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). The peripheral blood (PB) revealed an abnormal expansion of LGL that were CD3-, CD16- and CD56+, and had natural killer activity. In situ EBER-1 hybridization of the PB mononuclear cells showed the presence of Epstein-Barr virus (EBV) in the LGL as well as in lymphocytes infiltrating the tonsils and colon. Southern blotting with an EBV-terminal repetitive sequence probe demonstrated clonal proliferation of EBV+ cells. The patient received allo-PBSCT from his HLA-matched sister with a conditioning regimen involving the use of cyclophosphamide and fractionated total body irradiation. The patient promptly recovered trilineage haematopoiesis without graft-versus-host disease, and has been in complete remission without therapy for 10 months since allo-PBSCT, suggesting that allo-PBSCT could eradicate the NK-LGL leukaemic cells.
Original language | English (US) |
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Pages (from-to) | 1279-1282 |
Number of pages | 4 |
Journal | Bone marrow transplantation |
Volume | 21 |
Issue number | 12 |
DOIs | |
State | Published - 1998 |
Externally published | Yes |
Keywords
- Epstein-barr virus
- Large granular lymphocytic leukaemia
- Natural killer cells
- Peripheral blood stem cell transplantation