Sulfur-containing therapeutics in the treatment of Alzheimer’s disease

Haizhou Zhu, Venkateshwara Dronamraju, Wei Xie, Swati S. More

Research output: Contribution to journalReview articlepeer-review

Abstract

Sulfur is widely existent in natural products and synthetic organic compounds as organosulfur, which are often associated with a multitude of biological activities. OBenzothiazole, in which benzene ring is fused to the 4,5-positions of the thiazolerganosulfur compounds continue to garner increasing amounts of attention in the field of medicinal chemistry, especially in the development of therapeutic agents for Alzheimer’s disease (AD). AD is a fatal neurodegenerative disease and the primary cause of age-related dementia posing severe societal and economic burdens. Unfortunately, there is no cure for AD. A lot of research has been conducted on sulfur-containing compounds in the context of AD due to their innate antioxidant potential and some are currently being evaluated in clinical trials. In this review, we have described emerging trends in the field, particularly the concept of multi-targeting and formulation of disease-modifying strategies. SAR, pharmacological targets, in vitro/vivo ADMET, efficacy in AD animal models, and applications in clinical trials of such sulfur compounds have also been discussed. This article provides a comprehensive review of organosulfur-based AD therapeutic agents and provides insights into their future development. [Figure not available: see fulltext.].

Original languageEnglish (US)
Pages (from-to)305-352
Number of pages48
JournalMedicinal Chemistry Research
Volume30
Issue number2
DOIs
StatePublished - Feb 2021

Bibliographical note

Funding Information:
This work was supported in part by the Research Endowment funds from the Center for Drug Design (CDD) at the University of Minnesota, Minneapolis, and by the NIH grant # R01AG062469.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Keywords

  • AD
  • ADMET
  • Clinical trials
  • SAR

PubMed: MeSH publication types

  • Journal Article

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