19F nuclear magnetic resonance studies of lipid bilayer systems. 1

M. P.N. Gent; I. M. Armitage; J. H. Prestegard

doi:10.1021/ja00429a002

¹⁹F nuclear magnetic resonance studies of lipid bilayer systems. 1

M. P.N. Gent, I. M. Armitage, J. H. Prestegard

Biochemistry, Molecular Biology, and Biophysics (TMED)

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Abstract

A fluorinated lipid, 1-palmitoyl-2-8,8-difiuoropalmitoyl-sn-glycero-3-phosphorylcholine, has been synthesized and the dynamic properties of lipid bilayer systems containing this molecule have been studied using fluorine-19 NMR. Spin-lattice relaxation rates and nuclear Overhauser effects have been measured over a range of temperatures and the results have been interpreted in terms of correlation times for specific motions involving the gem-difluoromethylene group. The correlation times are shown to be consistent with and ¹³C relaxation data of similar lipid bilayer systems. The data, however, prove to be particularly valuable in characterizing a motion on the time scale of translational diffusion.

Original language	English (US)
Pages (from-to)	3749-3755
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	98
Issue number	13
DOIs	https://doi.org/10.1021/ja00429a002
State	Published - Jun 1 1976

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title = "19F nuclear magnetic resonance studies of lipid bilayer systems. 1",

abstract = "A fluorinated lipid, 1-palmitoyl-2-8,8-difiuoropalmitoyl-sn-glycero-3-phosphorylcholine, has been synthesized and the dynamic properties of lipid bilayer systems containing this molecule have been studied using fluorine-19 NMR. Spin-lattice relaxation rates and nuclear Overhauser effects have been measured over a range of temperatures and the results have been interpreted in terms of correlation times for specific motions involving the gem-difluoromethylene group. The correlation times are shown to be consistent with and 13C relaxation data of similar lipid bilayer systems. The data, however, prove to be particularly valuable in characterizing a motion on the time scale of translational diffusion.",

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AU - Gent, M. P.N.

AU - Armitage, I. M.

AU - Prestegard, J. H.

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AB - A fluorinated lipid, 1-palmitoyl-2-8,8-difiuoropalmitoyl-sn-glycero-3-phosphorylcholine, has been synthesized and the dynamic properties of lipid bilayer systems containing this molecule have been studied using fluorine-19 NMR. Spin-lattice relaxation rates and nuclear Overhauser effects have been measured over a range of temperatures and the results have been interpreted in terms of correlation times for specific motions involving the gem-difluoromethylene group. The correlation times are shown to be consistent with and 13C relaxation data of similar lipid bilayer systems. The data, however, prove to be particularly valuable in characterizing a motion on the time scale of translational diffusion.

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¹⁹F nuclear magnetic resonance studies of lipid bilayer systems. 1

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