TY - JOUR
T1 - Superactivated platelets
T2 - Thrombus regulators, thrombin generators, and potential clinical targets
AU - Mazepa, Marshall
AU - Hoffman, Maureane
AU - Monroe, Dougald
PY - 2013/8
Y1 - 2013/8
N2 - Platelets contribute to hemostasis by forming the platelet plug and then contributing to coagulation by providing a catalytic surface where thrombin generation occurs efficiently. This catalytic activity, known as the platelet procoagulant response, is being recognized as a nuanced response. This review examines platelets' response to strong stimuli, which results in the formation of a platelet subpopulation (superactivated platelets) with several unique properties, including enhanced procoagulant activity. These platelets contribute uniquely to thrombus architecture and seem to have thrombus regulatory activity. Superactivated platelets' role in diseases of thrombosis and hemostasis, as either potentiating or mitigating factors, is not currently known, but may be an important pharmacological target.
AB - Platelets contribute to hemostasis by forming the platelet plug and then contributing to coagulation by providing a catalytic surface where thrombin generation occurs efficiently. This catalytic activity, known as the platelet procoagulant response, is being recognized as a nuanced response. This review examines platelets' response to strong stimuli, which results in the formation of a platelet subpopulation (superactivated platelets) with several unique properties, including enhanced procoagulant activity. These platelets contribute uniquely to thrombus architecture and seem to have thrombus regulatory activity. Superactivated platelets' role in diseases of thrombosis and hemostasis, as either potentiating or mitigating factors, is not currently known, but may be an important pharmacological target.
KW - Hemostasis
KW - Phosphatidylserine
KW - Platelet
KW - Procoagulant
KW - activation
UR - http://www.scopus.com/inward/record.url?scp=84881012996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881012996&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.113.301790
DO - 10.1161/ATVBAHA.113.301790
M3 - Review article
C2 - 23864724
AN - SCOPUS:84881012996
SN - 1079-5642
VL - 33
SP - 1747
EP - 1752
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 8
ER -