Superparamagnetic nanoparticles encapsulated in lipid vesicles for advanced magnetic hyperthermia and biodetection

Javier Alonso, Hafsa Khurshid, Jagannath Devkota, Zohreh Nemati, Nawal K. Khadka, Hariharan Srikanth, Jianjun Pan, Manh Huong Phan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A multifunctional nanocomposite formed by superparamagnetic maghemite nanoparticles of 12.8 ± 1.7 nm diameter encapsulated in lipid unilamellar vesicles (i.e., magnetoliposomes) was prepared using size exclusion chromatography (SEC). The quality of the synthesized nanoparticles was characterized by transmission electron microscopy and X-ray diffraction measurements. Using a modified Langevin model, we analyzed the magnetic measurement data. We found that the SEC prepared magnetoliposomes possess superparamagnetic characteristics. We also performed calorimetric based magnetic hyperthermia measurement to quantify field dependent heating efficiency of the obtained magnetoliposomes. A heating efficiency of ∼160 W/g at 800 Oe and 310 kHz was obtained. Finally, we used magnetoreactance-based biodetection to explore the effect of magnetoliposomes on magneto-impedance (MI) and magneto-reactance (MX) ratios. Compared to pure vesicles, magnetoliposomes were found to increase the MI and MX ratios by ∼1.0% and 4.5%, respectively. Together, our magnetic hyperthermia and magneto-detection measurements indicate that our SEC prepared magnetoliposomes exhibit good qualities for hyperthermia and biosensing applications.

Original languageEnglish (US)
Article number083904
JournalJournal of Applied Physics
Volume119
Issue number8
DOIs
StatePublished - Feb 28 2016

Fingerprint Dive into the research topics of 'Superparamagnetic nanoparticles encapsulated in lipid vesicles for advanced magnetic hyperthermia and biodetection'. Together they form a unique fingerprint.

Cite this