Suppression by naloxone of water intake induced by deprevation and hypertonic saline in intact and hypophysectomized rats

David R. Brown, Michael S. Blank, Stephen G. Holtzman

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Abstract

Naloxone, an opiate antagonist, was administered to intact and hypophysectomized male rats following hypertonic saline pretreatment or 12 hr water deprivation. Water intake following hypertonic saline or water deprevation was reduced by 0.01 - 10 mg/kg of naloxone in a dose-related fashion in both intact and hypophysectomized rats. Water consumption induced by hypertonic saline administration appeared to be more susceptible to the suppressant effects of naloxone than did that evoked by water deprevation. These results demonstrate that naloxone reduces water intake in the rat following intracellular dehydration by hypertonic saline administration, as well as after general dehydration induced by water deprevation. Furthermore, the suppressant effects of naloxone on water intake do not appear to involve pituitary endorphins, although a possible involvement of antidiuretic hormone in these effects cannot be excluded.

Original languageEnglish (US)
Pages (from-to)1535-1542
Number of pages8
JournalLife Sciences
Volume26
Issue number18
DOIs
StatePublished - May 5 1980

Bibliographical note

Funding Information:
I. This investigation was supported in part by USPHS Grants TO1 GM00179, DA00541, Research Scientist Development Award K02 DA00008 to S.G.H., and by an Emory University McCandless Research Fund Grant to M.S.B.

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