Suppression of fixed-ratio operant behavior by β-endorphin

L. Lichtblau; L. H. Fossom; S. B. Sparber

Suppression of fixed-ratio operant behavior by β-endorphin

L. Lichtblau, L. H. Fossom, S. B. Sparber

Diagnostic and Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Long-Evans hooded rats maintained on a fixed-ratio (FR15) schedule of food reinforcement were given 0.3, 1.5 or 2.9 nmole (1, 5 or 10 μg) of synthetic camel β-endorphin. This produced a dose-related suppression of FR15 responding during the 30 min behavioral session with an ED50 of 0.7 nmole. On a molar basis, β-endorphin is 21 times more potent than morphine in suppressing fixed-ratio responding.

Original language	English (US)
Pages (from-to)	No. 355
Journal	Pharmacologist
Volume	19
Issue number	2
State	Published - Jan 1 1977

OpenUrl availability

Full text

Cite this

@article{5c45012bdd784186a7c48dfdbc101136,

title = "Suppression of fixed-ratio operant behavior by β-endorphin",

abstract = "Long-Evans hooded rats maintained on a fixed-ratio (FR15) schedule of food reinforcement were given 0.3, 1.5 or 2.9 nmole (1, 5 or 10 μg) of synthetic camel β-endorphin. This produced a dose-related suppression of FR15 responding during the 30 min behavioral session with an ED50 of 0.7 nmole. On a molar basis, β-endorphin is 21 times more potent than morphine in suppressing fixed-ratio responding.",

author = "L. Lichtblau and Fossom, {L. H.} and Sparber, {S. B.}",

year = "1977",

month = jan,

day = "1",

language = "English (US)",

volume = "19",

pages = "No. 355",

journal = "Pharmacologist",

issn = "0031-7004",

number = "2",

}

TY - JOUR

T1 - Suppression of fixed-ratio operant behavior by β-endorphin

AU - Lichtblau, L.

AU - Fossom, L. H.

AU - Sparber, S. B.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - Long-Evans hooded rats maintained on a fixed-ratio (FR15) schedule of food reinforcement were given 0.3, 1.5 or 2.9 nmole (1, 5 or 10 μg) of synthetic camel β-endorphin. This produced a dose-related suppression of FR15 responding during the 30 min behavioral session with an ED50 of 0.7 nmole. On a molar basis, β-endorphin is 21 times more potent than morphine in suppressing fixed-ratio responding.

AB - Long-Evans hooded rats maintained on a fixed-ratio (FR15) schedule of food reinforcement were given 0.3, 1.5 or 2.9 nmole (1, 5 or 10 μg) of synthetic camel β-endorphin. This produced a dose-related suppression of FR15 responding during the 30 min behavioral session with an ED50 of 0.7 nmole. On a molar basis, β-endorphin is 21 times more potent than morphine in suppressing fixed-ratio responding.

UR - http://www.scopus.com/inward/record.url?scp=19244378036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19244378036&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:19244378036

SN - 0031-7004

VL - 19

SP - No. 355

JO - Pharmacologist

JF - Pharmacologist

IS - 2

ER -

Suppression of fixed-ratio operant behavior by β-endorphin

Abstract

OpenUrl availability

Other files and links

Fingerprint

Cite this