Surface-based imaging methods for high-resolution functional magnetic resonance imaging

David Ress, Sankari Dhandapani, Sucharit Katyal, Clint Greene, Chandra Bajaj

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional magnetic resonance imaging (fMRI) has become an exceedingly popular technique for studies of human brain activity. Typically, fMRI is performed with >3-mm sampling, so that the imaging data can be regarded as two-dimensional samples that roughly average through the typically 1.5-4-mm thickness of cerebral cortex. The use of higher spatial resolutions, <1.5-mm sampling, complicates the use of fMRI, as one must now consider activity variations within the depth of the brain. We present a set of surface-based methods to exploit the use of high-resolution fMRI for depth analysis. These methods utilize white-matter segmentations coupled with deformable-surface algorithms to create a smooth surface representation at the gray-white interface. These surfaces provide vertex positions and surface normals, vector references for depth calculations. That information enables averaging schemes that can increase contrast-to-noise ratio, as well as permitting the direct analysis of depth profiles of functional activity in the human brain.

Original languageEnglish (US)
Title of host publicationComputational Modeling of Objects Represented in Images - Second International Symposium, CompIMAGE 2010, Proceedings
Pages130-140
Number of pages11
DOIs
StatePublished - May 21 2010
Event2nd International Symposium on Computational Modeling of Objects Represented in Images, Fundamentals, Methods and Applications, CompIMAGE 2010 - Buffalo, NY, United States
Duration: May 5 2010May 7 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6026 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other2nd International Symposium on Computational Modeling of Objects Represented in Images, Fundamentals, Methods and Applications, CompIMAGE 2010
CountryUnited States
CityBuffalo, NY
Period5/5/105/7/10

Keywords

  • Brain
  • Laminae
  • MRI
  • Neuroimaging
  • fMRI

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