TY - JOUR
T1 - Surface proteins involved in T cell costimulation
AU - Mondino, A.
AU - Jenkins, Marc
PY - 1994
Y1 - 1994
N2 - The activation and eventual clonal expansion of individual antigen- specific CD4+ T cell clones are dependent on the production of autocrine growth factors such as interleukin-2 (IL-2). The specificity of CD4+ T cell activation is imparted by T cell antigen receptor (TCR) recognition of peptide antigens bound to class II major histocompatibility complex (MHC)- encoded molecules on the surface of antigen-presenting cells (APCs), for example B cells, macrophages, and dendritic cells. To induce maximal IL-2 production by T cells, however, APCs must also provide non-antigen-specific costimulatory signals. Recent work indicates that APC-derived costimulatory signals play a critical role in determining whether lymphokine production, apoptotic cell death, or functional anergy is induced by TCR engagement. This information has allowed immunologists to manipulate costimulatory molecules to prevent allograft rejection and enhance tumor immunity. Here we review current information on the biologic effects of, and signal transduction pathways engaged by, several known receptor-ligand pairs that transduce costimulatory signals in T cells. Special emphasis will be placed on the interaction of CD28 on the T cell with its ligands, B7-1, B7-2, and B7-3 on the APC.
AB - The activation and eventual clonal expansion of individual antigen- specific CD4+ T cell clones are dependent on the production of autocrine growth factors such as interleukin-2 (IL-2). The specificity of CD4+ T cell activation is imparted by T cell antigen receptor (TCR) recognition of peptide antigens bound to class II major histocompatibility complex (MHC)- encoded molecules on the surface of antigen-presenting cells (APCs), for example B cells, macrophages, and dendritic cells. To induce maximal IL-2 production by T cells, however, APCs must also provide non-antigen-specific costimulatory signals. Recent work indicates that APC-derived costimulatory signals play a critical role in determining whether lymphokine production, apoptotic cell death, or functional anergy is induced by TCR engagement. This information has allowed immunologists to manipulate costimulatory molecules to prevent allograft rejection and enhance tumor immunity. Here we review current information on the biologic effects of, and signal transduction pathways engaged by, several known receptor-ligand pairs that transduce costimulatory signals in T cells. Special emphasis will be placed on the interaction of CD28 on the T cell with its ligands, B7-1, B7-2, and B7-3 on the APC.
KW - B7
KW - CD28
KW - T cell antigen receptor
KW - anergy
KW - lymphokine mRNA
KW - signal transduction
UR - http://www.scopus.com/inward/record.url?scp=0028291947&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028291947&partnerID=8YFLogxK
U2 - 10.1002/jlb.55.6.805
DO - 10.1002/jlb.55.6.805
M3 - Review article
C2 - 7910841
AN - SCOPUS:0028291947
SN - 0741-5400
VL - 55
SP - 805
EP - 815
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 6
ER -