Surgical Menopause and Frailty Risk in Community-Dwelling Older Women: Study of Osteoporotic Fractures

Grace Huang, Andrea Coviello, Michael P. LaValley, Kristine E. Ensrud, Jane A. Cauley, Peggy M. Cawthon, Lisa Fredman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: To determine whether women with surgical menopause have a higher risk of frailty than naturally menopausal women. Design: Prospective cohort study with up to 18 years of follow-up. Setting: Four U.S clinical centers. Participants: Community-dwelling white women aged 65 and older (mean 71.2±5.2) enrolled in the Study of Osteoporotic Fractures (N=7,699). Measurements: Surgical menopause was based on participant self-report of having undergone bilateral oophorectomy before menopause. The outcome was incident frailty, classified as robust, prefrail, frail, or death at 4 follow-up interviews, conducted 6 to 18 years after baseline. Information on baseline serum total testosterone concentrations was available for 541 participants. Results: At baseline, 12.6% reported surgical menopause. Over the follow-up period, 22.0% died, and 10.1% were classified as frail, 39.7% as prefrail, and 28.3% as robust. Surgically menopausal women had significantly lower total serum testosterone levels (13.2 ± 7.8 ng/dL) than naturally menopausal women (21.7 ± 14.8 ng/dL) (p=0.000), although they were not at greater risk of frailty (adjusted odds ratio (aOR)=0.94, 95% confidence interval (CI)=0.72–1.22), prefrailty (aOR=0.96, 95% CI=0.80–1.10), or death (aOR=1.17, 95% CI=0.97–1.42) after adjusting for age, body mass index, and number of instrumental activity of daily living impairments. There was no evidence that oral estrogen use modified these associations. Conclusion: In postmenopausal women, surgical menopause was not associated with greater risk for frailty than natural menopause, even in the absence of estrogen therapy. Future prospective studies are needed to investigate hormonal mechanisms involved in development of frailty in older postmenopausal women. J Am Geriatr Soc 66:2172–2177, 2018.

Original languageEnglish (US)
Pages (from-to)2172-2177
Number of pages6
JournalJournal of the American Geriatrics Society
Volume66
Issue number11
DOIs
StatePublished - Nov 2018

Bibliographical note

Funding Information:
Financial Disclosure: National Institutes of Health provides funding support for the SOF. The National Institute on Aging (NIA) provides support under Grants R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, R01 AG027576, R01 AG026720, R01 AG18037, and R21 AG050428. Additional funding support was also provided by National Heart, Lung, and Blood Institute Grant K08 HL132122–02 Conflict of Interest: The authors have no conflicts of interest to disclose.

Funding Information:
Financial Disclosure: National Institutes of Health provides funding support for the SOF. The National Institute on Aging (NIA) provides support under Grants R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, R01 AG027576, R01 AG026720, R01 AG18037, and R21 AG050428. Additional funding support was also provided by National Heart, Lung, and Blood Institute Grant K08 HL132122?02 Conflict of Interest: The authors have no conflicts of interest to disclose. Author Contributions: Drs. Huang, Lavalley and Fredman had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Huang, Fredman, Coviello, Lavalley, Ensrud. Acquisition, analysis, or interpretation of data: All authors. Drafting of manuscript: Huang, Coviello, Lavalley, Fredman. Critical revision of manuscript for important intellectual content: Huang, Coviello, Lavalley, Ensrud, Cauley, Fredman. Statistical analysis: Huang, Lavalley, Fredman. Sponsor's Role: None.

Publisher Copyright:
© 2018, Copyright the Authors Journal compilation © 2018, The American Geriatrics Society

Keywords

  • frailty
  • postmenopausal
  • surgical menopause
  • testosterone

Fingerprint

Dive into the research topics of 'Surgical Menopause and Frailty Risk in Community-Dwelling Older Women: Study of Osteoporotic Fractures'. Together they form a unique fingerprint.

Cite this