Abstract
Background: The GAS study is an international RCT to evaluate neurodevelopmental outcome comparing general plus regional anesthesia versus regional anesthesia alone in 722 neonates and infants who had inguinal hernia repair up to 60 weeks of postmenstrual age. This paper comprises a secondary descriptive analysis of hernias, aspects of surgery and outcomes. Methods: The incidence of unilateral and bilateral hernias, side preponderance, predictive factors for bilateral hernias and surgical approaches were collated. Follow-up outcome data were examined at 2 years. Results: Of 711 eligible patients, there were 679 with hernia data showing that 321 hernias were right-sided, 190 left and 168 bilateral. Male to female ratio was 5:1. Of those with unilateral hernias, 25.8% underwent contralateral exploration and in these cases a patent processus vaginalis was found in 68.9%. Bilateral hernias were more common in younger and female patients. At 2 years there was a recurrence rate of 0.99% and in 2.7% of patients a hernia was evident on the contralateral side (metachrony), and this was unrelated to the anesthesia technique. Conclusions: Bilateral hernias are associated with lower gestational age at birth and female gender. There was a low incidence of complications and the anesthesia technique did not affect surgical outcome. Level of evidence: Level 1 evidence from prospective treatment study.
Original language | English (US) |
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Pages (from-to) | 1643-1650 |
Number of pages | 8 |
Journal | Journal of Pediatric Surgery |
Volume | 53 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2018 |
Bibliographical note
Funding Information:Australia: The Australian National Health & Medical Research Council (Project Grants # 1002906 and 491226 ); Australian and New Zealand College of Anaesthetists (Project Grant # 11/021 and 07/012 ); The Murdoch Childrens Research Institute . This study was supported by the Victorian Government’s Operational Infrastructure Support Program .
Funding Information:
Canada: Canadian Institute of Health Research (Project Grant # MCT-98031 ), Canadian Anesthesiologists’ Society , Pfizer Canada Inc .
Funding Information:
UK: Health Technologies Assessment-National Institute for Health Research UK (Project Grant #07/01/05)
Funding Information:
Italy: Italian Ministry of Heath , Ricerca Finalizzata (Project Grant # RF-2011-02347532 )
Funding Information:
All hospitals and centers were generously supported by departmental funding.
Publisher Copyright:
© 2018 Elsevier Inc.
Keywords
- Anesthesia
- Infant
- Inguinal hernia repair
- Neonate
- Outcome