Sustained human chemosignal unconsciously alters brain function

Suma Jacob, Leann H. Kinnunen, John Metz, Malcolm Cooper, Martha K. McClintock

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

The human chemosignal, Δ4,16-androstadien-3-one modulates psychological state without being consciously discernible as an odor. This study demonstrates that Δ4,16-androstadien-3-one (androstadienone) alters cerebral glucose utilization both in subcortical regions and in areas of the neocortex not exclusively associated with olfaction. These widely distributed changes are consistent with modulation of an integrated neural network for regulation of emotional and attentional states. This is the first study to demonstrate the effects of a sustained chemosignal on brain metabolism and to show that they are similar to those of long acting chemical substances that affect psychological states. Moreover, this provides the first evidence that a human chemosignal has distributed effects on cortical processes and brain metabolism even when it is not detected consciously.

Original languageEnglish (US)
Pages (from-to)2391-2394
Number of pages4
JournalNeuroreport
Volume12
Issue number11
DOIs
StatePublished - Aug 8 2001

Keywords

  • Attention
  • Brain imaging
  • Chemosignals
  • Emotion
  • Glucose metabolism
  • Odors
  • Olfaction
  • PET
  • Pheromones
  • Sensorimotor
  • Steroids

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