Abstract
Castleman disease is a rare lymphoproliferative disorder, which presents in a unicentric or multicentric fashion. Multicentric Castleman disease (MCD) is associated with significant systemic symptoms, in part related to the underlying role of interleukin-6 in disease pathogenesis. Treatment for MCD has not been well established and prognosis has historically been poor. We present a case of severe MCD in a pediatric patient who has shown sustained remission following multi-agent chemotherapy and targeted maintenance therapy with the interleukin-6 receptor inhibitor, tocilizumab. This represents the first case report of sustained remission of MCD in a pediatric patient following discontinuation of tocilizumab therapy.
Original language | English (US) |
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Pages (from-to) | 737-739 |
Number of pages | 3 |
Journal | Pediatric Blood and Cancer |
Volume | 61 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2014 |
Keywords
- Anakinra
- CHOP
- Multicentric Castleman disease
- Tocilizumab