TY - JOUR
T1 - Synaptic organization and ionic basis of on and off channels in mudpuppy retina
T2 - II. Chloride-dependent ganglion cell mechanisms
AU - Miller, Robert F.
AU - Dacheux, Ramon F.
PY - 1976/6/1
Y1 - 1976/6/1
N2 - Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neqrons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP’s) are preceded by (EPSP’s) excitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
AB - Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neqrons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP’s) are preceded by (EPSP’s) excitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
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U2 - 10.1085/jgp.67.6.661
DO - 10.1085/jgp.67.6.661
M3 - Article
C2 - 932669
AN - SCOPUS:0017071234
SN - 0022-1295
VL - 67
SP - 661
EP - 678
JO - Journal of General Physiology
JF - Journal of General Physiology
IS - 6
ER -