Synergistic action of clotrimazole and sulfamethoxazole on Candida albicans and related species

W. H. Beggs; george a sarosi; N. M. Steele

Synergistic action of clotrimazole and sulfamethoxazole on Candida albicans and related species

W. H. Beggs, george a sarosi, N. M. Steele

Research output: Contribution to journal › Article › peer-review

Abstract

The antifungal drug clotrimazole (CTM) has an uncertain future with respect to treatment of the systemic mycoses. To explore further the chemotherapeutic potential of this drug, the authors have been studying in vitro effects of low level CTM in combination with other drugs against Candida species. Results with CTM and sulfamethoxazole (SMX) are presented here. A subinhibitory concentration of SMX (50 μg./ml.) in combination with a weak inhibitory level of CTM (1.0 μg./ml.) exerted marked fungistatic effects on 4 different strains of Candida albicans. Combined activity exceeded that of CTM alone and was interpreted as drug synergism. Similar results were obtained with strains of Candida tropicalis and Candida parapsilosis.

Original language	English (US)
Pages (from-to)	623-629
Number of pages	7
Journal	Current Therapeutic Research - Clinical and Experimental
Volume	20
Issue number	4 II
State	Published - Jan 1 1976
Externally published	Yes

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title = "Synergistic action of clotrimazole and sulfamethoxazole on Candida albicans and related species",

abstract = "The antifungal drug clotrimazole (CTM) has an uncertain future with respect to treatment of the systemic mycoses. To explore further the chemotherapeutic potential of this drug, the authors have been studying in vitro effects of low level CTM in combination with other drugs against Candida species. Results with CTM and sulfamethoxazole (SMX) are presented here. A subinhibitory concentration of SMX (50 μg./ml.) in combination with a weak inhibitory level of CTM (1.0 μg./ml.) exerted marked fungistatic effects on 4 different strains of Candida albicans. Combined activity exceeded that of CTM alone and was interpreted as drug synergism. Similar results were obtained with strains of Candida tropicalis and Candida parapsilosis.",

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T1 - Synergistic action of clotrimazole and sulfamethoxazole on Candida albicans and related species

AU - Beggs, W. H.

AU - sarosi, george a

AU - Steele, N. M.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - The antifungal drug clotrimazole (CTM) has an uncertain future with respect to treatment of the systemic mycoses. To explore further the chemotherapeutic potential of this drug, the authors have been studying in vitro effects of low level CTM in combination with other drugs against Candida species. Results with CTM and sulfamethoxazole (SMX) are presented here. A subinhibitory concentration of SMX (50 μg./ml.) in combination with a weak inhibitory level of CTM (1.0 μg./ml.) exerted marked fungistatic effects on 4 different strains of Candida albicans. Combined activity exceeded that of CTM alone and was interpreted as drug synergism. Similar results were obtained with strains of Candida tropicalis and Candida parapsilosis.

AB - The antifungal drug clotrimazole (CTM) has an uncertain future with respect to treatment of the systemic mycoses. To explore further the chemotherapeutic potential of this drug, the authors have been studying in vitro effects of low level CTM in combination with other drugs against Candida species. Results with CTM and sulfamethoxazole (SMX) are presented here. A subinhibitory concentration of SMX (50 μg./ml.) in combination with a weak inhibitory level of CTM (1.0 μg./ml.) exerted marked fungistatic effects on 4 different strains of Candida albicans. Combined activity exceeded that of CTM alone and was interpreted as drug synergism. Similar results were obtained with strains of Candida tropicalis and Candida parapsilosis.

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