Synergistic antiproliferative activity of tumor necrosis factor alpha (TNF-α) and lovastatin

M. K. Sora, A. A. Kruszewski, T. Stoklosa, J. Czyzyk, W. Lasek, J. Malejczyk, M. Jakobisiak

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14 Scopus citations

Abstract

We assessed the antiproliferative effect of tumor necrosis factor alpha (TNF-α) and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, alone and in combination, on two murine tumor cell lines. Recombinant TNF-α inhibited proliferation of murine MmB16 melanoma cells in a concentration-dependent fashion but stimulated growth of murine L1210 leukemia cells at 0.1 ng/ml concentration. Lovastatin inhibited proliferation both of murine MmB16 melanoma cells and of murine L1210 leukemia cells in a concentration-dependent fashion. In combination with tumor necrosis factor alpha lovastatin inhibited synergistically growth of both cell lines as assessed by isobologram analysis. Our data show that lovastatin, a cholesterol synthesis inhibitor, introduced to the clinic to treat hyercholesterolemia, used either as a single agent or in combination with TNF-α inhibits growth of MmB16 melanoma and L1210 leukemia cells.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume42
Issue number4
StatePublished - Dec 1 1994
Externally publishedYes

Keywords

  • antiproliferative activity
  • lovastatin
  • tumor necrosis factor alpha

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