Abstract
The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.
Original language | English (US) |
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Pages (from-to) | 4575-4577 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 57 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2013 |
Externally published | Yes |