TY - JOUR
T1 - Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop
AU - Prasanna, Pataje G.S.
AU - Blakely, William F.
AU - Bertho, Jean Marc
AU - Chute, John P.
AU - Cohen, Eric P.
AU - Goans, Ronald E.
AU - Grace, Marcy B.
AU - Lillis-Hearne, Patricia K.
AU - Lloyd, David C.
AU - Lutgens, Ludy C.H.W.
AU - Meineke, Viktor
AU - Ossetrova, Natalia I.
AU - Romanyukha, Alexander
AU - Saba, Julie D.
AU - Weisdorf, Daniel J.
AU - Wojcik, Andrzej
AU - Yukihara, Eduardo G.
AU - Pellmar, Terry C.
PY - 2010/2
Y1 - 2010/2
N2 - Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.
AB - Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.
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U2 - 10.1667/RR1993.1
DO - 10.1667/RR1993.1
M3 - Article
C2 - 20095857
AN - SCOPUS:75149180035
SN - 0033-7587
VL - 173
SP - 245
EP - 253
JO - Radiation research
JF - Radiation research
IS - 2
ER -