Synteny perturbations between wheat homoeologous chromosomes caused by locus duplications and deletions correlate with recombination rates

Eduard D. Akhunov, Alina R. Akhunova, Anna M. Linkiewicz, Jorge Dubcovsky, David Hummel, Gerry Lazo, Shiaoman Chao, Olin D. Anderson, Jacques David, Lili Qi, Benjamin Echalier, Bikram S. Gill, Miftahudin, J. Perry Gustafson, Mauricio La Rota, Mark E. Sorrells, Deshui Zhang, Henry T. Nguyen, Venugopal Kalavacharla, Khwaja HossainShahryar F. Kianian, Junhua Peng, Nora L.V. Lapitan, Emily J. Wennerlind, Vivienne Nduati, James A. Anderson, Deepak Sidhu, Kulvinder S. Gill, Patrick E. McGuire, Calvin O. Qualset, Jan Dvorak

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Loci detected by Southern blot hybridization of 3,977 expressed sequence tag unigenes were mapped into 159 chromosome bins delineated by breakpoints of a series of overlapping deletions. These data were used to assess synteny levels along homoeologous chromosomes of the wheat A, B, and D genomes, in relation to both bin position on the centromere-telomere axis and the gradient of recombination rates along chromosome arms. Synteny level decreased with the distance of a chromosome region from the centromere. It also decreased with an increase in recombination rates along the average chromosome arm. There were twice as many unique loci in the B genome than in the A and D genomes, and synteny levels between the B genome chromosomes and the A and D genome homoeologues were lower than those between the A and D genome homoeologues. These differences among the wheat genomes were attributed to differences in the mating systems of wheat diploid ancestors. Synteny perturbations were characterized in 31 paralogous sets of loci with perturbed synteny. Both insertions and deletions of loci were detected and both preferentially occurred in high recombination regions of chromosomes.

Original languageEnglish (US)
Pages (from-to)10836-10841
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number19
DOIs
StatePublished - Sep 16 2003

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