Abstract
Human toll-like receptor (hTLR)-8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogues encompassing four chemotypes are described.
Original language | English (US) |
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Title of host publication | Methods in Molecular Biology |
Publisher | Humana Press Inc. |
Pages | 29-44 |
Number of pages | 16 |
DOIs | |
State | Published - 2017 |
Publication series
Name | Methods in Molecular Biology |
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Volume | 1494 |
ISSN (Print) | 1064-3745 |
Bibliographical note
Funding Information:This work was supported by NIH/NIAID contracts HSN272200900033C and HHSN272201400056C.
Publisher Copyright:
© Springer Science+Business Media New York 2017.
Keywords
- Innate immunity
- TLR8
- TLR8 agonists
- Vaccine adjuvants