2-Methyl-1, 8-naphthyridine-3-carboxylic acid hydrazide 2 on reaction with CS2 in the presence of KOH affords 5-mercapto-2-(2′-methyl-1′, 8′-naphthyridin-3′-yl)-1, 3, 4-oxadiazole 3, which is converted into 4-amino-5-mercapto-3-(2′-methyl-1′, 8′-naphthyridin-3′-yl)-1, 2, 4-triazole 4 by the reaction with hydrazine hydrate. Cyclization of 4 with aromatic acids in refluxing POCl3 yields 6-aryl-3-(2′-methyl-1′, 8′-naphthyridin-3′-yl)-1, 2, 4-triazolo[3, 4-b][1, 3, 4]thiadiazoles 5. Compounds 5 have been tested for their antibacterial activity.
|Original language||English (US)|
|Number of pages||3|
|Journal||Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry|
|State||Published - Jul 1 1996|