Synthesis and biological activity of 4-methylestradiol

Xiao Dong Qian, Yusuf J. Abul-Hajj

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5 Scopus citations

Abstract

The synthesis of 4-methylestradiol (4-ME2) was carried out by reductive aromatization of 4-methyl-1,4-androstadiene-3-one-17β-ol. The relative binding affinity of 4-ME2 was found to be 10 and 25% of estradiol at 0 and 25°C, respectively. 4-ME2 had considerably weaker uterotrophic activity relative to estrone and was found to have no antiuterotrophic activity.

Original languageEnglish (US)
Pages (from-to)745-747
Number of pages3
JournalJournal of Steroid Biochemistry
Volume35
Issue number6
DOIs
StatePublished - May 1990

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