Synthesis and biological activity of 4-methylestradiol

Xiao Dong Qian; Yusuf J. Abul-Hajj

doi:10.1016/0022-4731(90)90318-M

Synthesis and biological activity of 4-methylestradiol

Xiao Dong Qian, Yusuf J. Abul-Hajj

Medicinal Chemistry

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Abstract

The synthesis of 4-methylestradiol (4-ME₂) was carried out by reductive aromatization of 4-methyl-1,4-androstadiene-3-one-17β-ol. The relative binding affinity of 4-ME₂ was found to be 10 and 25% of estradiol at 0 and 25°C, respectively. 4-ME₂ had considerably weaker uterotrophic activity relative to estrone and was found to have no antiuterotrophic activity.

Original language	English (US)
Pages (from-to)	745-747
Number of pages	3
Journal	Journal of Steroid Biochemistry
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/0022-4731(90)90318-M
State	Published - May 1990

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abstract = "The synthesis of 4-methylestradiol (4-ME2) was carried out by reductive aromatization of 4-methyl-1,4-androstadiene-3-one-17β-ol. The relative binding affinity of 4-ME2 was found to be 10 and 25% of estradiol at 0 and 25°C, respectively. 4-ME2 had considerably weaker uterotrophic activity relative to estrone and was found to have no antiuterotrophic activity.",

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Synthesis and biological activity of 4-methylestradiol

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