Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

Ye Tang; Ramaiah Muthyala; Robert Vince

doi:10.1016/j.bmc.2006.05.029

Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

Ye Tang, Ramaiah Muthyala, Robert Vince

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A series of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. The (E)-isomers were obtained to compare the side chain geometry effect on antiviral activity.

Original language	English (US)
Pages (from-to)	5866-5875
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1016/j.bmc.2006.05.029
State	Published - Sep 1 2006

Keywords

Antiviral
Bioisosteres
Carboacyclic
Nucleosides

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Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

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Keywords

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