Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

Ye Tang, Ramaiah Muthyala, Robert Vince

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A series of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. The (E)-isomers were obtained to compare the side chain geometry effect on antiviral activity.

Original languageEnglish (US)
Pages (from-to)5866-5875
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number17
DOIs
StatePublished - Sep 1 2006

Keywords

  • Antiviral
  • Bioisosteres
  • Carboacyclic
  • Nucleosides

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