Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors

Medicine & Life Sciences

• HIV Integrase Inhibitors 100%
• purine 68%
• HIV Integrase 52%
• Metals 51%
• Acids 45%
• Integrase Inhibitors 44%
• Ligands 42%
• picolinamide 30%
• Palladium 22%
• quinoline 21%
• Anti-HIV Agents 20%
• Integrases 19%
• Amides 17%
• Structure-Activity Relationship 17%
• HIV 10%

Chemical Compounds

• Integrase Inhibitor 94%
• Purine 60%
• Aryl Group 33%
• Metal 26%
• Ligand 26%
• Picolinamide 23%
• Anti Human Immunodeficiency Virus Agent 21%
• Acid 20%
• Structure-Activity Relationship 12%
• Bioactivity 10%
• Amide 10%
• Substitution Reaction 9%
• Molecule 5%