Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

Ahmed Kamal, O. Srinivas, P. Ramulu, G. Ramesh, P. Praveen Kumar, M. Shiva Kumar

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.

Original languageEnglish (US)
Pages (from-to)4337-4350
Number of pages14
JournalBioorganic and Medicinal Chemistry
Volume12
Issue number16
DOIs
StatePublished - Aug 15 2004

Bibliographical note

Funding Information:
We thank the National Cancer Institute, Maryland for the in vitro anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Cytotoxicity
  • DNA binding affinity
  • Pyrrolobenzodiazepine dimers

Fingerprint Dive into the research topics of 'Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers'. Together they form a unique fingerprint.

Cite this