Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor

Zhijun Wu; Gunda I. Georg; Brian E. Cathers; John V. Schloss

doi:10.1016/0960-894X(96)00153-9

Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor

Zhijun Wu, Gunda I. Georg, Brian E. Cathers, John V. Schloss

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

A monocyclic 3-amino-β-lactam analog of the dipeptide Phe-Gly methyl ester has been synthesized as a potential protease inhibitor. This β-lactam is a non-time-dependent inhibitor of α-chymotrypsin, carboxypeptidase Y, and cathepsin G.

Original language	English (US)
Pages (from-to)	983-986
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	8
DOIs	https://doi.org/10.1016/0960-894X(96)00153-9
State	Published - Apr 23 1996

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title = "Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor",

abstract = "A monocyclic 3-amino-β-lactam analog of the dipeptide Phe-Gly methyl ester has been synthesized as a potential protease inhibitor. This β-lactam is a non-time-dependent inhibitor of α-chymotrypsin, carboxypeptidase Y, and cathepsin G.",

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AU - Wu, Zhijun

AU - Georg, Gunda I.

AU - Cathers, Brian E.

AU - Schloss, John V.

PY - 1996/4/23

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AB - A monocyclic 3-amino-β-lactam analog of the dipeptide Phe-Gly methyl ester has been synthesized as a potential protease inhibitor. This β-lactam is a non-time-dependent inhibitor of α-chymotrypsin, carboxypeptidase Y, and cathepsin G.

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Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor

Abstract

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