Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries

Laxminarayan Bhat; Yanbin Liu; Sam F. Victory; Richard H. Himes; Gunda I. Georg

doi:10.1016/S0960-894X(98)00551-4

Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries

Laxminarayan Bhat, Yanbin Liu, Sam F. Victory, Richard H. Himes, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

Original language	English (US)
Pages (from-to)	3181-3186
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	22
DOIs	https://doi.org/10.1016/S0960-894X(98)00551-4
State	Published - Nov 17 1998

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Access

10.1016/S0960-894X(98)00551-4

Fingerprint Dive into the research topics of 'Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries'. Together they form a unique fingerprint.

Cite this

@article{4fec0ed7a98040979b8c50cf42473794,

title = "Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries",

abstract = "A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.",

author = "Laxminarayan Bhat and Yanbin Liu and Victory, {Sam F.} and Himes, {Richard H.} and Georg, {Gunda I.}",

year = "1998",

month = nov,

day = "17",

doi = "10.1016/S0960-894X(98)00551-4",

language = "English (US)",

volume = "8",

pages = "3181--3186",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "22",

}

TY - JOUR

T1 - Synthesis and evaluation of paclitaxel C7 derivatives

T2 - Solution phase synthesis of combinatorial libraries

AU - Bhat, Laxminarayan

AU - Liu, Yanbin

AU - Victory, Sam F.

AU - Himes, Richard H.

AU - Georg, Gunda I.

PY - 1998/11/17

Y1 - 1998/11/17

N2 - A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

AB - A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

UR - http://www.scopus.com/inward/record.url?scp=0032542047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032542047&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(98)00551-4

DO - 10.1016/S0960-894X(98)00551-4

M3 - Article

C2 - 9873699

AN - SCOPUS:0032542047

VL - 8

SP - 3181

EP - 3186

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 22

ER -

Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries

Abstract

Bibliographical note

Access

Other files and links

Cite this