Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries

Laxminarayan Bhat, Yanbin Liu, Sam F. Victory, Richard H. Himes, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

Original languageEnglish (US)
Pages (from-to)3181-3186
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number22
DOIs
StatePublished - Nov 17 1998

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Copyright 2017 Elsevier B.V., All rights reserved.

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