Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues

Laurent Bonnac, Sarah E. Lee, Guy T. Giuffredi, Lucy M. Elphick, Alexandra A. Anderson, Emma S. Child, David J. Mann, Véronique Gouverneur

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of the tetrafluorinated naphthyl-C-nucleotide.

Original languageEnglish (US)
Pages (from-to)1445-1454
Number of pages10
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number6
DOIs
StatePublished - 2010
Externally publishedYes

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