A new series of structurally diverse 2-chloro-8-methyl quinoline imides (2a-g) were synthesized by conversion of 2-chloro-8- methyl quinoline-3- carboxaldehyde (1) to its amide (2) followed by coupling of different benzoyl chlorides. The newly synthesized compounds were characterized by spectral and elemental analysis and studied for their antioxidant properties by three in vitro assays like 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, microsomal lipid peroxidation (LPO) assay and ferric reducing power assay. Butylated hydroxy anisole (BHA) was used as a reference antioxidant and the comparative study with newly synthesized compounds was also done. Among the analogues compound (2f), bearing three hydroxyl groups showed predominant activity.
|Original language||English (US)|
|Number of pages||5|
|Journal||Drug Invention Today|
|State||Published - Dec 1 2012|
- 2-chloro-8- methylquinoline-3- carboxaldehyde
- 2-chloro-8-methyl quinoline imides
- Antioxidant activity