Synthesis and reactivity of novel γ-phosphate modified ATP analogues

Sarah E. Lee, Lucy M. Elphick, Alexandra A. Anderson, Laurent Bonnac, Emma S. Child, David J. Mann, Véronique Gouverneur

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29 Scopus citations

Abstract

We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27kip1 is also presented.

Original languageEnglish (US)
Pages (from-to)3804-3807
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number14
DOIs
StatePublished - Jul 15 2009
Externally publishedYes

Bibliographical note

Funding Information:
We thank the Biotechnology and Biological Sciences Research Council and Cancer Research UK for funding.

Keywords

  • ATP
  • Alkene
  • Alkyne
  • Azide
  • Kinase
  • Phosphorylation

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