Abstract
Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating peptide libraries using either solid-phase peptide synthesis or phage display are described. Methods for screening such libraries and their application in studying several important biological problems are also reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-23 |
| Number of pages | 23 |
| Journal | Current Topics in Peptide and Protein Research |
| Volume | 15 |
| State | Published - 2014 |
Bibliographical note
Funding Information:This work was supported by the National Institutes of Health (NIH GM 084152), the National Science Foundation (NSF CHE-1308655) and the University of Minnesota.
Keywords
- C-terminal peptide libraries
- Combinatorial libraries
- Peptide libraries
- Phage display
- Protein libraries
- Screening
- Solid-phase peptide synthesis