Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating peptide libraries using either solid-phase peptide synthesis or phage display are described. Methods for screening such libraries and their application in studying several important biological problems are also reported.
|Original language||English (US)|
|Number of pages||23|
|Journal||Current Topics in Peptide and Protein Research|
|State||Published - 2014|
Bibliographical noteFunding Information:
This work was supported by the National Institutes of Health (NIH GM 084152), the National Science Foundation (NSF CHE-1308655) and the University of Minnesota.
- C-terminal peptide libraries
- Combinatorial libraries
- Peptide libraries
- Phage display
- Protein libraries
- Solid-phase peptide synthesis