Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

Subash C. Jonnalagadda, Jonathan S. Cruz, Ryan J. Connell, Patricia M Scott, Venkatram R Mereddy

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.

Original languageEnglish (US)
Pages (from-to)4314-4317
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number30
DOIs
StatePublished - Jul 29 2009

Bibliographical note

Funding Information:
We thank the Departments of Chemistry and Biochemistry, Rowan University, and University of Minnesota Duluth for the resources and funding. Partial support for this work was provided by research grants from the National Institutes of Health (CA129993) (VRM) and Whiteside Institute for Clinical Research (VRM).

Keywords

  • Boron neutron capture therapy
  • Carboranes
  • Isonitriles
  • Low-density lipoprotein
  • Multicomponent reactions

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