The carcinogenic tobacco‐specific nitrosamines 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) and N′‐nitrosonornicotine (NNN), as well as the model compound 4‐(carbethoxynitrosamino)‐1‐(3‐pyridyl)‐1‐butanone, were synthesized with tritium at the 5‐position of the pyridine ring. In each case, the tritium labelled compound was prepared by catalytic tritium replacement of the corresponding brominated precursor.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|State||Published - Jul 1988|
- Tritium labeled tobacco‐specific nitrosamines