A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.
Bibliographical noteFunding Information:
Financial support of this work by the National Institute of General Medical Sciences is gratefully acknowledged, P50-GM069663 .
Copyright 2016 Elsevier B.V., All rights reserved.