Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase

Daniel A. Harki, Jason D. Graci, Jocelyn P. Edathil, Christian Castro, Craig E. Cameron, Blake R. Peterson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

(Figure Presented) Something in the way. Nucleoside analogues that enhance the frequency of viral mutagenesis are a promising new class of antiviral agents. We report that 5-nitroindole ribonucleoside triphosphate (1) can be universally incorporated opposite each native RNA base by the RNA-dependent RNA polymerase (RdRP) from poliovirus, and inhibits this enzyme more potently than the triphosphate metabolite of the antiviral drug, ribavirin.

Original languageEnglish (US)
Pages (from-to)1359-1362
Number of pages4
JournalChemBioChem
Volume8
Issue number12
DOIs
StatePublished - Aug 13 2007

Keywords

  • Antiviral agents
  • Mutagenesis
  • Nucleobases
  • Poliovirus
  • Polymerases
  • Universal base

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