Synthesis of amino acid derived enaminones via wolff rearrangement using vinylogous amides as carbon nucleophiles

Hajime Seki, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Cyclic enaminones were synthesized in high yields from amino acids in two steps via Wolff rearrangement. The cyclization represents a rare 6-exo-dig cyclization involving a ketene as an electrophile. No racemization was observed during this reaction.

Original languageEnglish (US)
Pages (from-to)15512-15513
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number44
DOIs
StatePublished - Nov 10 2010

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