Synthesis of an Acylphosphate Driven by a Proton Gradient. A Model for H+-ATPase

Ian J. Colton, Romas J. Kazlauskas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We describe the first model for a proton pump, H+-ATPase. This model uses the energy from an indirect transfer of two protons from a solution at pH 0.3 to a solution at pH 10 to drive the synthesis of a high-energy phosphate, citraconyl phosphate.

Original languageEnglish (US)
Pages (from-to)7005-7006
Number of pages2
JournalJournal of Organic Chemistry
Volume57
Issue number26
DOIs
StatePublished - Dec 1 1992

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