Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

Ahmed Kamal; P. Ramulu; O. Srinivas; G. Ramesh; P. Praveen Kumar

doi:10.1016/j.bmcl.2004.06.069

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

Ahmed Kamal, P. Ramulu, O. Srinivas, G. Ramesh, P. Praveen Kumar

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

Original language	English (US)
Pages (from-to)	4791-4794
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2004.06.069
State	Published - Sep 20 2004
Externally published	Yes

Bibliographical note

Funding Information:
We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to P.R., O.S., G.R. and P.P.K.

Keywords

Benzimidazoles
Cytotoxicity
DNA-binding ability
Hoechst-33258
Pyrrolobenzodiazepine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity",

abstract = "Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.",

keywords = "Benzimidazoles, Cytotoxicity, DNA-binding ability, Hoechst-33258, Pyrrolobenzodiazepine",

author = "Ahmed Kamal and P. Ramulu and O. Srinivas and G. Ramesh and Kumar, {P. Praveen}",

note = "Funding Information: We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to P.R., O.S., G.R. and P.P.K.",

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AU - Kamal, Ahmed

AU - Ramulu, P.

AU - Srinivas, O.

AU - Ramesh, G.

AU - Kumar, P. Praveen

N1 - Funding Information: We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to P.R., O.S., G.R. and P.P.K.

PY - 2004/9/20

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AB - Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

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KW - Cytotoxicity

KW - DNA-binding ability

KW - Hoechst-33258

KW - Pyrrolobenzodiazepine

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ER -

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

Abstract

Bibliographical note

Keywords

UN SDGs

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