TY - JOUR
T1 - Synthesis of hydroxyapatite, β-Tricalcium phosphate and biphasic calcium phosphate particles to act as local delivery carriers of curcumin
T2 - Loading, release and in vitro studies
AU - Xidaki, Despoina
AU - Agrafioti, Panagiota
AU - Diomatari, Dimitra
AU - Kaminari, Archontia
AU - Tsalavoutas-Psarras, Eleftherios
AU - Alexiou, Polyxeni
AU - Psycharis, Vasilios
AU - Tsilibary, Effie C.
AU - Silvestros, Spyridon
AU - Sagnou, Marina
N1 - Publisher Copyright:
© 2018 by the authors.
PY - 2018/4/12
Y1 - 2018/4/12
N2 - The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling.
AB - The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling.
KW - Biphasic calcium phosphates
KW - Curcumin
KW - Delivery
KW - Hydroxyapatite
KW - β-Tricalcium phosphate
UR - http://www.scopus.com/inward/record.url?scp=85045447102&partnerID=8YFLogxK
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U2 - 10.3390/ma11040595
DO - 10.3390/ma11040595
M3 - Article
C2 - 29649121
AN - SCOPUS:85045447102
SN - 1996-1944
VL - 11
JO - Materials
JF - Materials
IS - 4
M1 - 595
ER -