Synthesis of methylenebis (Phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide

Krzysztof Felczak; Krzysztof W. Pankiewicz

doi:10.1080/15257770.2011.575909

Synthesis of methylenebis (Phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide

Krzysztof Felczak, Krzysztof W. Pankiewicz

Center for Drug Design

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4 Scopus citations

Abstract

The synthesis of metabolically stable methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide (NAD) is reported. In contrast to natural pyrophosphates, these NAD analogues are able to penetrate the cell membrane and can be used as probes in cellular assays.

Original language	English (US)
Pages (from-to)	512-523
Number of pages	12
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	30
Issue number	7-8
DOIs	https://doi.org/10.1080/15257770.2011.575909
State	Published - Jul 2011

Keywords

IMPDH
NAD analogues
NAD kinase

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abstract = "The synthesis of metabolically stable methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide (NAD) is reported. In contrast to natural pyrophosphates, these NAD analogues are able to penetrate the cell membrane and can be used as probes in cellular assays.",

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KW - NAD analogues

KW - NAD kinase

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Synthesis of methylenebis (Phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide

Abstract

Keywords

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