Synthesis of novel C2 and C2-C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P. Praveen Kumar

doi:10.1016/S0960-894X(03)00718-2

Synthesis of novel C2 and C2-C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

Ahmed Kamal, O. Srinivas, P. Ramulu, G. Ramesh, P. Praveen Kumar

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Synthesis of C2 and C2-C8 linked pyrrolobenzodiazepine-naphthalimide hybrids have been prepared that exhibit significant DNA-binding affinity and cytotoxicity.

Original language	English (US)
Pages (from-to)	3577-3581
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(03)00718-2
State	Published - Oct 20 2003

Bibliographical note

Funding Information:
We thank the National Cancer Institute, Maryland for the primary anticancer assay in human cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

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abstract = "Synthesis of C2 and C2-C8 linked pyrrolobenzodiazepine-naphthalimide hybrids have been prepared that exhibit significant DNA-binding affinity and cytotoxicity.",

author = "Ahmed Kamal and O. Srinivas and P. Ramulu and G. Ramesh and Kumar, {P. Praveen}",

note = "Funding Information: We thank the National Cancer Institute, Maryland for the primary anticancer assay in human cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.",

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AU - Ramulu, P.

AU - Ramesh, G.

AU - Kumar, P. Praveen

N1 - Funding Information: We thank the National Cancer Institute, Maryland for the primary anticancer assay in human cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

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Synthesis of novel C2 and C2-C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

Abstract

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