Synthesis of N3,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity

Peiyuan Wang, Laurent Hollecker, Krzysztof W. Pankiewicz, Steven E. Patterson, Tony Whitaker, Tamara R. McBrayer, Phillip M. Tharnish, Robert W. Sidwell, Lieven J. Stuyver, Michael J. Otto, Raymond F. Schinazi, Kyoichi A. Watanabe

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Abstract

A novel anti-hepatitis C virus (HCV) agent, N3,5′-cyclo-4- (β-D-ribofuranosyl)-vic-triazolo(4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5- nitropyridine.

Original languageEnglish (US)
Pages (from-to)6100-6103
Number of pages4
JournalJournal of medicinal chemistry
Volume47
Issue number24
DOIs
StatePublished - Nov 18 2004

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