Synthesis of oligodeoxynucleotides containing the c-nucleoside and 2- deoxy-2’-fluoro-ara-nucleoside moieties by the h-phosphonate method.1.2

Ivan Rosenberg; Jaume Farras Soler; Zdenek Tocik; Wu Yon Ren; Lech A. Ciszewski; Pavol Kois; Krzysztof Pankiewicz; Maria Spassova; Kyoichi A. Watanabe

doi:10.1080/07328319308017834

Synthesis of oligodeoxynucleotides containing the c-nucleoside and 2- deoxy-2’-fluoro-ara-nucleoside moieties by the h-phosphonate method.^1.2

Ivan Rosenberg, Jaume Farras Soler, Zdenek Tocik, Wu Yon Ren, Lech A. Ciszewski, Pavol Kois, Krzysztof Pankiewicz, Maria Spassova, Kyoichi A. Watanabe

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23 Scopus citations

Abstract

A module type, computer-controlled, multipurpose synthesizer displaying a novel device for the transport of liquids, was constructed and used in the synthesis of oligomers containing some C-nucleosides and 2,-deoxy-2,-fluoro-ara-nucleoside moieties. H-Phosphonate method was applied in terms of a further adjustment of construction features of the synthesizer versus chemistry of the process. Results of preliminary studies on the effects of the modified nucleosides on the stability of duplexes showed a clear tendency of destabilization of duplexes in the case of C-nucleosides while fluorinated nucleosides in most cases stabilize the formed duplexes.

Original language	English (US)
Pages (from-to)	381-401
Number of pages	21
Journal	Nucleosides and Nucleotides
Volume	12
Issue number	3-4
DOIs	https://doi.org/10.1080/07328319308017834
State	Published - Mar 1 1993
Externally published	Yes

Bibliographical note

Funding Information:
This investigation was supported in parts by funds from the National Cancer Institute, National Institutes of Health, U. S. Department of Health and Human Services, Grants CA18601 and CA33907.

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@article{5be91b3a35a6445b9ae5bd8ec4ecfbdb,

title = "Synthesis of oligodeoxynucleotides containing the c-nucleoside and 2- deoxy-2{\textquoteright}-fluoro-ara-nucleoside moieties by the h-phosphonate method.1.2",

abstract = "A module type, computer-controlled, multipurpose synthesizer displaying a novel device for the transport of liquids, was constructed and used in the synthesis of oligomers containing some C-nucleosides and 2,-deoxy-2,-fluoro-ara-nucleoside moieties. H-Phosphonate method was applied in terms of a further adjustment of construction features of the synthesizer versus chemistry of the process. Results of preliminary studies on the effects of the modified nucleosides on the stability of duplexes showed a clear tendency of destabilization of duplexes in the case of C-nucleosides while fluorinated nucleosides in most cases stabilize the formed duplexes.",

author = "Ivan Rosenberg and Soler, {Jaume Farras} and Zdenek Tocik and Ren, {Wu Yon} and Ciszewski, {Lech A.} and Pavol Kois and Krzysztof Pankiewicz and Maria Spassova and Watanabe, {Kyoichi A.}",

note = "Funding Information: This investigation was supported in parts by funds from the National Cancer Institute, National Institutes of Health, U. S. Department of Health and Human Services, Grants CA18601 and CA33907.",

year = "1993",

month = mar,

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doi = "10.1080/07328319308017834",

language = "English (US)",

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pages = "381--401",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

publisher = "Taylor and Francis Ltd.",

number = "3-4",

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T1 - Synthesis of oligodeoxynucleotides containing the c-nucleoside and 2- deoxy-2’-fluoro-ara-nucleoside moieties by the h-phosphonate method.1.2

AU - Rosenberg, Ivan

AU - Soler, Jaume Farras

AU - Tocik, Zdenek

AU - Ren, Wu Yon

AU - Ciszewski, Lech A.

AU - Kois, Pavol

AU - Pankiewicz, Krzysztof

AU - Spassova, Maria

AU - Watanabe, Kyoichi A.

N1 - Funding Information: This investigation was supported in parts by funds from the National Cancer Institute, National Institutes of Health, U. S. Department of Health and Human Services, Grants CA18601 and CA33907.

PY - 1993/3/1

Y1 - 1993/3/1

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