Synthesis of oximidine II by a copper-mediated reductive ene-yne macrocyclization

Christopher M. Schneider; Kriangsak Khownium; Wei Li; Jared T. Spletstoser; Torsten Haack; Gunda Georg

doi:10.1002/anie.201103081

Synthesis of oximidine II by a copper-mediated reductive ene-yne macrocyclization

Christopher M. Schneider, Kriangsak Khownium, Wei Li, Jared T. Spletstoser, Torsten Haack, Gunda Georg

Medicinal Chemistry

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Abstract

Holy macro! An intramolecular copper-mediated reductive Castro-Stephens reaction furnished a key macrocyclic triene intermediate for the total synthesis of oximidine II (see scheme). The total synthesis of the natural product was completed and the mechanism of this unprecedented key reaction was deduced.

Original language	English (US)
Pages (from-to)	7855-7857
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	34
DOIs	https://doi.org/10.1002/anie.201103081
State	Published - Aug 16 2011

Keywords

anticancer agents
copper-mediated reactions
macrocyclization
natural products
total synthesis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Synthesis of oximidine II by a copper-mediated reductive ene-yne macrocyclization",

abstract = "Holy macro! An intramolecular copper-mediated reductive Castro-Stephens reaction furnished a key macrocyclic triene intermediate for the total synthesis of oximidine II (see scheme). The total synthesis of the natural product was completed and the mechanism of this unprecedented key reaction was deduced.",

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AU - Khownium, Kriangsak

AU - Li, Wei

AU - Spletstoser, Jared T.

AU - Haack, Torsten

AU - Georg, Gunda

PY - 2011/8/16

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KW - copper-mediated reactions

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KW - natural products

KW - total synthesis

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Synthesis of oximidine II by a copper-mediated reductive ene-yne macrocyclization

Abstract

Keywords

UN SDGs

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