Abstract
A copper-mediated macrocyclization involving the reaction of a vinyl iodide and a terminal alkyne followed by an in situ reduction of the enyne intermediate is reported. The reaction generates a conjugated Z-double bond within a strained medium-size lactone, lactam, or ether macrocycle. A variety of macrocyclic compounds bearing different ring sizes and functionalities were synthesized. A complementary stepwise procedure was also developed for less strained ring systems.
Original language | English (US) |
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Pages (from-to) | 3902-3905 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 17 |
Issue number | 15 |
DOIs | |
State | Published - Aug 7 2015 |