The syntheses of the potent and selective serotonin reuptake complex radioligands [123I]‐ and [125I]5‐iodo‐6‐nitroquipazine (5‐iodo‐6‐nitro‐2‐piperazinylquinoline) are reported. A seven step synthetic sequence provided the BOC‐protected 5‐tributyltin‐6‐nitroquipazine precursor for radioiodination. End of synthesis radioiodination yields of ∼40% for 123I and ∼60% for 125I were achieved resulting in labelled products with high specific activities (>4000 and >2000 Ci/mmol, respectively) and radiochemical purities (>98%).
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|State||Published - Oct 1994|
- serotonin reuptake complex