The biomedically useful Cu(DHMPE) 2 + complex (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino]ethane, a water-soluble bidentate phosphine) is normally synthesized from expensive Cu(I) sources because the use of cheaper CuCl can lead to a variety of unwanted coordination complex by-products. A method is reported for the synthesis of Cu(DHMPE) 2 + from CuCl. Reaction of CuCl with DHMPE in methanol gave [Cu(DHMPE) 2]Cl, which is soluble in water and moderately soluble in methanol. The complex crystallized as a phosphine-bridged dimer, [Cu 2(DHMPE) 4]Cl 2, but 1H NMR DOSY experiments indicated the complex is mononuclear in solution. Reaction of CuCl with DHMPE in THF did not yield Cu(DHMPE) 2 +, except when a halide abstractor such as NaPF 6 was added.
Bibliographical noteFunding Information:
The National Science Foundation (CHE-0809393) is acknowledged for the support of this research.
Copyright 2012 Elsevier B.V., All rights reserved.
- Biomedically useful metal complex
- Copper phosphine complex
- Water-soluble coordination complex
- Water-soluble phosphine