Abstract
The biomedically useful Cu(DHMPE)2+ complex (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino]ethane, a water-soluble bidentate phosphine) is normally synthesized from expensive Cu(I) sources because the use of cheaper CuCl can lead to a variety of unwanted coordination complex by-products. A method is reported for the synthesis of Cu(DHMPE)2+ from CuCl. Reaction of CuCl with DHMPE in methanol gave [Cu(DHMPE)2]Cl, which is soluble in water and moderately soluble in methanol. The complex crystallized as a phosphine-bridged dimer, [Cu2(DHMPE) 4]Cl2, but 1H NMR DOSY experiments indicated the complex is mononuclear in solution. Reaction of CuCl with DHMPE in THF did not yield Cu(DHMPE)2+, except when a halide abstractor such as NaPF6 was added.
Original language | English (US) |
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Pages (from-to) | 30-34 |
Number of pages | 5 |
Journal | Polyhedron |
Volume | 45 |
Issue number | 1 |
DOIs | |
State | Published - Sep 19 2012 |
Externally published | Yes |
Bibliographical note
Funding Information:The National Science Foundation (CHE-0809393) is acknowledged for the support of this research.
Keywords
- Biomedically useful metal complex
- Copper phosphine complex
- Water-soluble coordination complex
- Water-soluble phosphine