Synthesis of the hydrophilic phosphine complex Cu(DHMPE) 2 + from Cu(I) chloride (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino] ethane, a water-soluble bidentate phosphine)

Bryan P. Nell, Charles D. Swor, Lev N. Zakharov, David R. Tyler

Research output: Contribution to journalArticlepeer-review

Abstract

The biomedically useful Cu(DHMPE) 2 + complex (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino]ethane, a water-soluble bidentate phosphine) is normally synthesized from expensive Cu(I) sources because the use of cheaper CuCl can lead to a variety of unwanted coordination complex by-products. A method is reported for the synthesis of Cu(DHMPE) 2 + from CuCl. Reaction of CuCl with DHMPE in methanol gave [Cu(DHMPE) 2]Cl, which is soluble in water and moderately soluble in methanol. The complex crystallized as a phosphine-bridged dimer, [Cu 2(DHMPE) 4]Cl 2, but 1H NMR DOSY experiments indicated the complex is mononuclear in solution. Reaction of CuCl with DHMPE in THF did not yield Cu(DHMPE) 2 +, except when a halide abstractor such as NaPF 6 was added.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalPolyhedron
Volume45
Issue number1
DOIs
StatePublished - Sep 19 2012
Externally publishedYes

Bibliographical note

Funding Information:
The National Science Foundation (CHE-0809393) is acknowledged for the support of this research.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Biomedically useful metal complex
  • Copper phosphine complex
  • Water-soluble coordination complex
  • Water-soluble phosphine

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