Synthesis of the hydrophilic phosphine complex Cu(DHMPE)2 + from Cu(I) chloride (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino] ethane, a water-soluble bidentate phosphine)

Bryan P. Nell; Charles D. Swor; Lev N. Zakharov; David R. Tyler

doi:10.1016/j.poly.2012.07.053

Synthesis of the hydrophilic phosphine complex Cu(DHMPE)₂ ⁺ from Cu(I) chloride (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino] ethane, a water-soluble bidentate phosphine)

Bryan P. Nell, Charles D. Swor, Lev N. Zakharov, David R. Tyler

Research output: Contribution to journal › Article › peer-review

Abstract

The biomedically useful Cu(DHMPE)₂⁺ complex (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino]ethane, a water-soluble bidentate phosphine) is normally synthesized from expensive Cu(I) sources because the use of cheaper CuCl can lead to a variety of unwanted coordination complex by-products. A method is reported for the synthesis of Cu(DHMPE)₂⁺ from CuCl. Reaction of CuCl with DHMPE in methanol gave [Cu(DHMPE)₂]Cl, which is soluble in water and moderately soluble in methanol. The complex crystallized as a phosphine-bridged dimer, [Cu₂(DHMPE) ₄]Cl₂, but ¹H NMR DOSY experiments indicated the complex is mononuclear in solution. Reaction of CuCl with DHMPE in THF did not yield Cu(DHMPE)₂⁺, except when a halide abstractor such as NaPF₆ was added.

Original language	English (US)
Pages (from-to)	30-34
Number of pages	5
Journal	Polyhedron
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.poly.2012.07.053
State	Published - Sep 19 2012
Externally published	Yes

Bibliographical note

Funding Information:
The National Science Foundation (CHE-0809393) is acknowledged for the support of this research.

Keywords

Biomedically useful metal complex
Copper phosphine complex
Water-soluble coordination complex
Water-soluble phosphine

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title = "Synthesis of the hydrophilic phosphine complex Cu(DHMPE)2 + from Cu(I) chloride (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino] ethane, a water-soluble bidentate phosphine)",

abstract = "The biomedically useful Cu(DHMPE)2+ complex (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino]ethane, a water-soluble bidentate phosphine) is normally synthesized from expensive Cu(I) sources because the use of cheaper CuCl can lead to a variety of unwanted coordination complex by-products. A method is reported for the synthesis of Cu(DHMPE)2+ from CuCl. Reaction of CuCl with DHMPE in methanol gave [Cu(DHMPE)2]Cl, which is soluble in water and moderately soluble in methanol. The complex crystallized as a phosphine-bridged dimer, [Cu2(DHMPE) 4]Cl2, but 1H NMR DOSY experiments indicated the complex is mononuclear in solution. Reaction of CuCl with DHMPE in THF did not yield Cu(DHMPE)2+, except when a halide abstractor such as NaPF6 was added.",

keywords = "Biomedically useful metal complex, Copper phosphine complex, Water-soluble coordination complex, Water-soluble phosphine",

author = "Nell, {Bryan P.} and Swor, {Charles D.} and Zakharov, {Lev N.} and Tyler, {David R.}",

note = "Funding Information: The National Science Foundation (CHE-0809393) is acknowledged for the support of this research. ",

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AU - Swor, Charles D.

AU - Zakharov, Lev N.

AU - Tyler, David R.

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