Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

Hui Cai; Jared Orwenyo; Javier Guenaga; John Giddens; Christian Toonstra; Richard T. Wyatt; Lai Xi Wang

doi:10.1039/c7cc02059g

Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

Hui Cai, Jared Orwenyo, Javier Guenaga, John Giddens, Christian Toonstra, Richard T. Wyatt, Lai Xi Wang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.

Original language	English (US)
Pages (from-to)	5453-5456
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	39
DOIs	https://doi.org/10.1039/c7cc02059g
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1039/c7cc02059g

http://europepmc.org/articles/pmc5518472

OpenUrl availability

Full text

Cite this

@article{e5e5e6b4ab804d54963ba4a827635f2f,

title = "Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies",

abstract = "We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.",

author = "Hui Cai and Jared Orwenyo and Javier Guenaga and John Giddens and Christian Toonstra and Wyatt, {Richard T.} and Wang, {Lai Xi}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc02059g",

language = "English (US)",

volume = "53",

pages = "5453--5456",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "39",

}

TY - JOUR

T1 - Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

AU - Cai, Hui

AU - Orwenyo, Jared

AU - Guenaga, Javier

AU - Giddens, John

AU - Toonstra, Christian

AU - Wyatt, Richard T.

AU - Wang, Lai Xi

PY - 2017

Y1 - 2017

N2 - We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.

AB - We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.

UR - http://www.scopus.com/inward/record.url?scp=85021684281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021684281&partnerID=8YFLogxK

U2 - 10.1039/c7cc02059g

DO - 10.1039/c7cc02059g

M3 - Article

C2 - 28466900

AN - SCOPUS:85021684281

SN - 1359-7345

VL - 53

SP - 5453

EP - 5456

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

Abstract

Bibliographical note

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this